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Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

ABSTRACT: We describe a multidrug-resistant Neisseria gonorrhoeae urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating penA-60.001. Global awareness of spreading ceftriaxone-resistant gonococcal strains that threaten recommended dual therapies is essential.

SUBMITTER: Golparian D 

PROVIDER: S-EPMC6341943 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Multidrug-resistant <i>Neisseria gonorrhoeae</i> isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

Golparian Daniel D   Rose Lisa L   Lynam Almida A   Mohamed Aia A   Bercot Beatrice B   Ohnishi Makoto M   Crowley Brendan B   Unemo Magnus M  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20181101 47

We describe a multidrug-resistant <i>Neisseria gonorrhoeae</i> urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating <  ...[more]

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