Ontology highlight
ABSTRACT:
SUBMITTER: Toyama Y
PROVIDER: S-EPMC6415961 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Toyama Yuki Y Kontani Kenji K Katada Toshiaki T Shimada Ichio I
Science advances 20190313 3
Ras-related C3 botulinum toxin substrate 1 (Rac1) plays critical roles in the maintenance of cell morphology by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states. Rac1 P29S mutant is known to strongly promote oncogenesis by facilitating its intrinsic GDP dissociation and thereby increasing the level of the GTP-bound state. Here, we used solution nuclear magnetic resonance spectroscopy to investigate the activation mechanism of the onc ...[more]