Ontology highlight
ABSTRACT:
SUBMITTER: Toyama Y
PROVIDER: S-EPMC6685717 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Toyama Yuki Y Kontani Kenji K Katada Toshiaki T Shimada Ichio I
Science advances 20190807 8
Ras-related C3 botulinum toxin substrate 1 (Rac1) functions as a molecular switch by cycling between an inactive guanosine diphosphate (GDP)-bound state and an active guanosine triphosphate (GTP)-bound state. An oncogenic mutant of Rac1, an N92I mutant, strongly promotes cell proliferation and subsequent oncogenic activities by facilitating the intrinsic GDP dissociation in the inactive GDP-bound state. Here, we used solution nuclear magnetic resonance spectroscopy to investigate the activation ...[more]