Sleep moderates the relationship between amyloid beta and memory recall.
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ABSTRACT:
SUBMITTER: Wilckens KA
PROVIDER: S-EPMC6416050 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Sleep moderates the relationship between amyloid beta and memory recall.
Wilckens Kristine A KA Tudorascu Dana L DL Snitz Beth E BE Price Julie C JC Aizenstein Howard J HJ Lopez Oscar L OL Erickson Kirk I KI Lopresti Brian J BJ Laymon Charles M CM Minhas Davneet D Mathis Chester A CA Buysse Daniel J DJ Klunk William E WE Cohen Ann D AD
Neurobiology of aging 20180726
Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer's disease, although Aβ alone may be insufficient to cause impairments. Modifiable health factors, including sleep, may mitigate functional symptoms of neurodegeneration. We assessed whether sleep moderated the relationship between Aβ and cognitive performance in 41 older adults, mean age 83 years. Sleep measures included actigraphy-assessed wake after sleep onset and total sleep time. Cognitive performance was assessed with memory recall, co ...[more]
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