Ontology highlight
ABSTRACT:
SUBMITTER: Therriault J
PROVIDER: S-EPMC8758492 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Therriault Joseph J Benedet Andrea L AL Pascoal Tharick A TA Mathotaarachchi Sulantha S Savard Melissa M Chamoun Mira M Thomas Emilie E Kang Min Su MS Lussier Firoza F Tissot Cecile C Soucy Jean-Paul JP Massarweh Gassan G Rej Soham S Saha-Chaudhuri Paramita P Poirier Judes J Gauthier Serge S Rosa-Neto Pedro P
Molecular psychiatry 20200311 10
APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and is associated with cerebral amyloid-β. However, the association between APOEε4 and tau pathology, the other major proteinopathy of Alzheimer's disease, has been controversial. Here, we sought to determine whether the relationship between APOEε4 and tau pathology is determined by local interactions with amyloid-β. We examined three independent samples of cognitively unimpaired, mild cognitive impairment a ...[more]