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Behavioural evidence for parallel outcome-sensitive and outcome-insensitive Pavlovian learning systems in humans.

ABSTRACT: There is a dichotomy in instrumental conditioning between goal-directed actions and habits that are distinguishable on the basis of their relative sensitivity to changes in outcome value. It is less clear whether a similar distinction applies in Pavlovian conditioning, where responses have been found to be predominantly outcome sensitive. To test for both devaluation insensitive and devaluation sensitive Pavlovian conditioning in humans, we conducted four experiments combining Pavlovian conditioning and outcome devaluation procedures while measuring multiple conditioned responses. Our results suggest that Pavlovian conditioning involves two distinct types of learning: one that learns the current value of the outcome which is sensitive to devaluation, and one that learns about the spatial localisation of the outcome which is insensitive to devaluation. Our findings have implications for the mechanistic understanding of Pavlovian conditioning and provide a more nuanced understanding of Pavlovian mechanisms that might contribute to a number of psychiatric disorders.

SUBMITTER: Pool ER

PROVIDER: S-EPMC6416744 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Behavioural evidence for parallel outcome-sensitive and outcome-insensitive Pavlovian learning systems in humans.

Pool Eva R ER Pauli Wolfgang M WM Kress Carolina S CS O'Doherty John P JP

Nature human behaviour 20190225 3

There is a dichotomy in instrumental conditioning between goal-directed actions and habits that are distinguishable on the basis of their relative sensitivity to changes in outcome value. It is less clear whether a similar distinction applies in Pavlovian conditioning, where responses have been found to be predominantly outcome sensitive. To test for both devaluation insensitive and devaluation sensitive Pavlovian conditioning in humans, we conducted four experiments combining Pavlovian conditio ...[more]

PMID: 30882043

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Project description:Reinforcement Learning has greatly influenced models of conditioning, providing powerful explanations of acquired behaviour and underlying physiological observations. However, in recent autoshaping experiments in rats, variation in the form of Pavlovian conditioned responses (CRs) and associated dopamine activity, have questioned the classical hypothesis that phasic dopamine activity corresponds to a reward prediction error-like signal arising from a classical Model-Free system, necessary for Pavlovian conditioning. Over the course of Pavlovian conditioning using food as the unconditioned stimulus (US), some rats (sign-trackers) come to approach and engage the conditioned stimulus (CS) itself - a lever - more and more avidly, whereas other rats (goal-trackers) learn to approach the location of food delivery upon CS presentation. Importantly, although both sign-trackers and goal-trackers learn the CS-US association equally well, only in sign-trackers does phasic dopamine activity show classical reward prediction error-like bursts. Furthermore, neither the acquisition nor the expression of a goal-tracking CR is dopamine-dependent. Here we present a computational model that can account for such individual variations. We show that a combination of a Model-Based system and a revised Model-Free system can account for the development of distinct CRs in rats. Moreover, we show that revising a classical Model-Free system to individually process stimuli by using factored representations can explain why classical dopaminergic patterns may be observed for some rats and not for others depending on the CR they develop. In addition, the model can account for other behavioural and pharmacological results obtained using the same, or similar, autoshaping procedures. Finally, the model makes it possible to draw a set of experimental predictions that may be verified in a modified experimental protocol. We suggest that further investigation of factored representations in computational neuroscience studies may be useful.

Dataset Information

Behavioural evidence for parallel outcome-sensitive and outcome-insensitive Pavlovian learning systems in humans.

Publications

Behavioural evidence for parallel outcome-sensitive and outcome-insensitive Pavlovian learning systems in humans.

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