Reduced White Matter Fiber Density in Autism Spectrum Disorder.
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ABSTRACT:
SUBMITTER: Dimond D
PROVIDER: S-EPMC6418389 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Reduced White Matter Fiber Density in Autism Spectrum Disorder.
Dimond Dennis D Schuetze Manuela M Smith Robert E RE Dhollander Thijs T Cho Ivy I Vinette Sarah S Ten Eycke Kayla K Lebel Catherine C McCrimmon Adam A Dewey Deborah D Connelly Alan A Bray Signe S
Cerebral cortex (New York, N.Y. : 1991) 20190401 4
Differences in brain networks and underlying white matter abnormalities have been suggested to underlie symptoms of autism spectrum disorder (ASD). However, robustly characterizing microstructural white matter differences has been challenging. In the present study, we applied an analytic technique that calculates structural metrics specific to differently-oriented fiber bundles within a voxel, termed "fixels". Fixel-based analyses were used to compare diffusion-weighted magnetic resonance imagin ...[more]
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