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Copper-Catalyzed, Ceric Ammonium Nitrate Mediated N-Arylation of Amines.

ABSTRACT: Cu-Catalyzed, ligand and base free cross-coupling of aryl boronic acids with primary and secondary amines has been reported. This 'Chan-Evans-Lam' reaction has revealed that at room temperature, catalytic copper(II) acetate and ceric ammonium nitrate (CAN) as an oxidant, N-arylation can result in an effective C-N bond formation. This air stable, practical, robust protocol enables a variety of functional group tolerance on both boronic acid and amine partners.

SUBMITTER: Gonela UM 

PROVIDER: S-EPMC6419960 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Copper-Catalyzed, Ceric Ammonium Nitrate Mediated <i>N</i>-Arylation of Amines.

Gonela Uma Maheshwar UM   Ablordeppey Seth Y SY  

New journal of chemistry = Nouveau journal de chimie 20190117 7

Cu-Catalyzed, ligand and base free cross-coupling of aryl boronic acids with primary and secondary amines has been reported. This 'Chan-Evans-Lam' reaction has revealed that at room temperature, catalytic copper(II) acetate and ceric ammonium nitrate (CAN) as an oxidant, N-arylation can result in an effective C-N bond formation. This air stable, practical, robust protocol enables a variety of functional group tolerance on both boronic acid and amine partners. ...[more]