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Mitochondria in cancer metabolism, an organelle whose time has come?

ABSTRACT: Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. More recently the contributions of mitochondria to cancer development and progression have become firmly established. This has led to the identification of novel targets and inhibitors being studied as new therapeutic approaches. This review will summarize the role of mitochondria in cancer and highlight several agents under development.

SUBMITTER: Anderson RG

PROVIDER: S-EPMC6420819 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Mitochondria in cancer metabolism, an organelle whose time has come?

Anderson Rebecca G RG Ghiraldeli Lais P LP Pardee Timothy S TS

Biochimica et biophysica acta. Reviews on cancer 20180526 1

Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. More recently the contributions of mitochondria to cancer development and progression have become firmly established. This has led to the identification of novel targets and inhibitors being studied as new therapeutic approaches. This review will summ ...[more]

PMID: 29807044

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