Ontology highlight
ABSTRACT:
SUBMITTER: Choi Y
PROVIDER: S-EPMC6423227 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Choi Youngeun Y Schmidt Carsten C Tinnefeld Philip P Bald Ilko I Rödiger Stefan S
Scientific reports 20190318 1
The DNA origami technique has great potential for the development of brighter and more sensitive reporters for fluorescence based detection schemes such as a microbead-based assay in diagnostic applications. The nanostructures can be programmed to include multiple dye molecules to enhance the measured signal as well as multiple probe strands to increase the binding strength of the target oligonucleotide to these nanostructures. Here we present a proof-of-concept study to quantify short oligonucl ...[more]