Ontology highlight
ABSTRACT:
SUBMITTER: Madden SK
PROVIDER: S-EPMC6423998 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Madden Sarah K SK Perez-Riba Albert A Itzhaki Laura S LS
Protein science : a publication of the Protein Society 20190401 4
Peptide display approaches, in which peptide epitopes of known binding activities are grafted onto stable protein scaffolds, have been developed to constrain the peptide in its bioactive conformation and to enhance its stability. However, peptide grafting can be a lengthy process requiring extensive computational modeling and/or optimisation by directed evolution techniques. In this study, we show that ultra-stable consensus-designed tetratricopeptide repeat (CTPR) proteins are amenable to the g ...[more]