Ontology highlight
ABSTRACT:
SUBMITTER: Shirin A
PROVIDER: S-EPMC6426249 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Shirin Afroza A Della Rossa Fabio F Klickstein Isaac I Russell John J Sorrentino Francesco F
PloS one 20190320 3
The Glucose-Insulin-Glucagon nonlinear model accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either insulin (monotherapy) or insulin and glucagon (dual therapy) that can optimally maintain the blood glucose level within desired limits after consumption of a meal and prevent the onset of both hypoglycemia and hyperglycemia. This problem is formulated as a nonlinear opt ...[more]