Ontology highlight
ABSTRACT:
SUBMITTER: Choi JK
PROVIDER: S-EPMC6428440 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Choi Jung Kyu JK He Xiaoming X
Journal of biomaterials and tissue engineering 20180701 7
The study of blastocyst differentiation from stem cells is still at its stage of infancy. In this study, a simple and efficient method was developed to derive blastocyst-like cell aggregates (BLCAs) from murine embryonic stem cells (mESCs). This was achieved by culturing the mESCs in non-adherent dishes.0020BLCAs (13±2 per million mESCs) were obtained in only 5 days and they were found to express the protein and gene markers of trophoblasts. Furthermore, the BLCAs showed the normal trophoblasts' ...[more]