Reduced signal for polygenic adaptation of height in UK Biobank.
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ABSTRACT:
SUBMITTER: Berg JJ
PROVIDER: S-EPMC6428572 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Reduced signal for polygenic adaptation of height in UK Biobank.
Berg Jeremy J JJ Harpak Arbel A Sinnott-Armstrong Nasa N Joergensen Anja Moltke AM Mostafavi Hakhamanesh H Field Yair Y Boyle Evan August EA Zhang Xinjun X Racimo Fernando F Pritchard Jonathan K JK Coop Graham G
eLife 20190321
Several recent papers have reported strong signals of selection on European polygenic height scores. These analyses used height effect estimates from the GIANT consortium and replication studies. Here, we describe a new analysis based on the the UK Biobank (UKB), a large, independent dataset. We find that the signals of selection using UKB effect estimates are strongly attenuated or absent. We also provide evidence that previous analyses were confounded by population stratification. Therefore, t ...[more]
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