Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC3758123 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
DNA repair 20111109 2
The DNA damage response (DDR) and the spindle assembly checkpoint (SAC) are two critical mechanisms by which mammalian cells maintain genome stability. There is a growing body of evidence that DDR elements and SAC components crosstalk. Here we report that Bub1 (budding uninhibited by benzimidazoles 1), one of the critical kinetochore proteins essential for SAC, is required for optimal DDRs. We found that knocking-down Bub1 resulted in prolonged H2AX foci and comet tail formation as well as hyper ...[more]