Unknown

Dataset Information

0

Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.

ABSTRACT: Three furan-containing scalarane sesterterpenoids (1?3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reaction of 2. The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6, the C-16 epimer of 5, showed no cytotoxicity at a concentration of 60 ??.

SUBMITTER: Lee YJ 

PROVIDER: S-EPMC6429051 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge <i>Scalarispongia</i> sp.

Lee Yeon-Ju YJ   Kim Su Hyun SH   Choi Hansol H   Lee Hyi-Seung HS   Lee Jong Seok JS   Shin Hee Jae HJ   Lee Jihoon J  

Molecules (Basel, Switzerland) 20190227 5

Three furan-containing scalarane sesterterpenoids (<b>1</b>⁻<b>3</b>) and a novel pyrrole-containing analog (<b>4</b>) were isolated from the sponge <i>Scalarispongia</i> species. Compound <b>3</b>, reported in the literature as a synthetic derivative of furoscalarol <b>2</b>, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (<b>5</b>, <b>6</b>) were obtained from the unintended reacti  ...[more]

Similar Datasets

Unknown Cytotoxic sesterterpenoids from a sponge Hippospongia sp.
| S-EPMC3397461 | biostudies-literature
Unknown Isolation of Scalarane-Type Sesterterpenoids from the Marine Sponge Dysidea sp. and Stereochemical Reassignment of 12-epi-Phyllactone D/E.
| S-EPMC8624410 | biostudies-literature
Unknown Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus.
| S-EPMC7281328 | biostudies-literature
Unknown Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90.
| S-EPMC5086919 | biostudies-literature
Unknown Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the Mushroom Neonothopanus&nbsp;nambi.
| S-EPMC8708503 | biostudies-literature
Unknown Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.
| S-EPMC2782894 | biostudies-literature
Unknown Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.
| S-EPMC6321518 | biostudies-literature
Unknown Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.
| S-EPMC4900817 | biostudies-literature
Unknown Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.
| S-EPMC4962020 | biostudies-literature
Unknown Halogenated cyclic peptides isolated from the sponge Corticium sp.
| S-EPMC2533844 | biostudies-literature