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Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.

ABSTRACT: Three furan-containing scalarane sesterterpenoids (1?3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reaction of 2. The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6, the C-16 epimer of 5, showed no cytotoxicity at a concentration of 60 ??.

SUBMITTER: Lee YJ

PROVIDER: S-EPMC6429051 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.

Lee Yeon-Ju YJ Kim Su Hyun SH Choi Hansol H Lee Hyi-Seung HS Lee Jong Seok JS Shin Hee Jae HJ Lee Jihoon J

Molecules (Basel, Switzerland) 20190227 5

Three furan-containing scalarane sesterterpenoids (1⁻3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reacti ...[more]

PMID: 30818810

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