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One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water.

ABSTRACT: A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of ?-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.

SUBMITTER: Chen L

PROVIDER: S-EPMC6429224 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water.

Chen Liang L Zhu Huajian H Wang Jiang J Liu Hong H

Molecules (Basel, Switzerland) 20190304 5

A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions. ...[more]

PMID: 30836604

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