Ontology highlight
ABSTRACT:
SUBMITTER: Caramenti P
PROVIDER: S-EPMC6430016 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chemical science 20190204 11
Enamides and enol ethers are valuable building blocks in synthetic chemistry, yet their stereoselective synthesis can be challenging. Herein, we report a new stereoselective synthesis of vinyl, aryl, alkynyl, alkyl and thio-substituted <i>Z</i>-enamides and enol ethers based on the use of vinylbenziodoxolone (VBX) reagents. The stable VBX reagents were synthesized by stereoselective addition of N- or O-nucleophiles on the corresponding alkynyl reagents in the presence of a catalytic amount of ce ...[more]