Impaired myocardial perfusion is associated with increasing end-systolic- and end-diastolic volumes in patients with non-ischemic systolic heart failure: a cross-sectional study using Rubidium-82 PET/CT.

ABSTRACT:

Background

Myocardial flow reserve (MFR, stress/rest myocardial blood flow) is a strong marker of myocardial vasomotor function. MFR is a predictor of adverse cardiac events in patients with non-ischemic systolic heart failure and previous studies using different methods have found association between myocardial blood flow and left ventricular dilatation. The aim of this study was to investigate whether there is an association between increasing end-systolic- and end-diastolic volumes (ESV and EDV) and MFR in these patients measured with Rubidium-82 positron emission tomography computed tomography (⁸²Rb-PET/CT) as a quantitative myocardial perfusion gold-standard.

Methods

We scanned 151 patients with non-ischemic heart failure with initial left ventricular ejectio

SUBMITTER: Byrne C 

PROVIDER: S-EPMC6431039 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature