Ontology highlight
ABSTRACT:
SUBMITTER: Hombach-Barrigah A
PROVIDER: S-EPMC6434042 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Hombach-Barrigah Antje A Bartsch Katharina K Smirlis Despina D Rosenqvist Heidi H MacDonald Andrea A Dingli Florent F Loew Damarys D Späth Gerald F GF Rachidi Najma N Wiese Martin M Clos Joachim J
Scientific reports 20190325 1
Leishmania parasites are thought to control protein activity at the post-translational level, e.g. by protein phosphorylation. In the pathogenic amastigote, the mammalian stage of Leishmania parasites, heat shock proteins show increased phosphorylation, indicating a role in stage-specific signal transduction. Here we investigate the impact of phosphosites in the L. donovani heat shock protein 90. Using a chemical knock-down/genetic complementation approach, we mutated 11 confirmed or presumed ph ...[more]