Dataset Information

SUPER: A blockwise curve-fitting method for accelerating MR parametric mapping with fast reconstruction.

ABSTRACT: PURPOSE:To investigate Shift Undersampling improves Parametric mapping Efficiency and Resolution (SUPER), a novel blockwise curve-fitting method for accelerating parametric mapping with very fast reconstruction. METHODS:SUPER uses interleaved k-space undersampling, which enables a blockwise decomposition of the otherwise large-scale cost function to improve the reconstruction efficiency. SUPER can be readily combined with SENSE to achieve at least 4-fold acceleration. D-factor, a parametric-mapping counterpart of g-factor, was proposed and formulated to compare spatially heterogeneous noise amplification because of different acceleration methods. As a proof-of-concept, SUPER/SUPER-SENSE was validated using T1 mapping, by comparing them to alternative model-based methods, including MARTINI and GRAPPATINI, via simulations, phantom imaging, and in vivo brain imaging (N = 5), over criteria of normalized root-mean-squares error (NRMSE), average d-factor, and computational time per voxel (TPV). A novel SUPER-SENSE MOLLI cardiac T1 -mapping sequence with improved resolution (1.4 mm × 1.4 mm) was compared to standard MOLLI (1.9 mm × 2.5 mm) in 8 healthy subjects. RESULTS:In brain imaging, 2-fold SUPER achieved lower NRMSE (0.04 ± 0.02 vs. 0.11 ± 0.02, P < 0.01), lower average d-factor (1.01 ± 0.002 vs. 1.12 ± 0.004, P < 0.001), and lower TPV (4.6 ms ± 0.2 ms vs. 79 ms ± 3 ms, P < 0.001) than 2-fold MARTINI. Similarly, 4-fold SUPER-SENSE achieved lower NRMSE (0.07 ± 0.01 vs. 0.13 ± 0.03, P = 0.02), lower average d-factor (1.15 ± 0.01 vs. 1.20 ± 0.01, P < 0.001), and lower TPV (4.0 ms ± 0.1 ms vs. 72 ms ± 3 ms, P < 0.001) than 4-fold GRAPPATINI. In cardiac T1 mapping, SUPER-SENSE MOLLI yielded similar myocardial T1 (1151 ms ± 63 ms vs. 1159 ms ± 32 ms, P = 0.6), slightly lower blood T1 (1643 ms ± 86 ms vs. 1680 ms ± 79 ms, P = 0.004), but improved spatial resolution compared with standard MOLLI in the same imaging time. CONCLUSION:SUPER and SUPER-SENSE provide fast model-based reconstruction methods for accelerating parametric mapping and improving its clinical appeal.

SUBMITTER: Hu C

PROVIDER: S-EPMC6435434 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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SUPER: A blockwise curve-fitting method for accelerating MR parametric mapping with fast reconstruction.

Hu Chenxi C Peters Dana C DC

Magnetic resonance in medicine 20190117 6

<h4>Purpose</h4>To investigate Shift Undersampling improves Parametric mapping Efficiency and Resolution (SUPER), a novel blockwise curve-fitting method for accelerating parametric mapping with very fast reconstruction.<h4>Methods</h4>SUPER uses interleaved k-space undersampling, which enables a blockwise decomposition of the otherwise large-scale cost function to improve the reconstruction efficiency. SUPER can be readily combined with SENSE to achieve at least 4-fold acceleration. D-factor, a ...[more]

PMID: 30656730

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Project description:PurposeWe aim to determine an advantageous approach for the acceleration of high spatial resolution 3D cardiac T2 relaxometry data by comparing the performance of different undersampling patterns and reconstruction methods over a range of acceleration rates.MethodsMulti-volume 3D high-resolution cardiac images were acquired fully and undersampled retrospectively using 1) optimal CAIPIRINHA and 2) a variable density random (VDR) sampling. Data were reconstructed using 1) multi-volume sensitivity encoding (SENSE), 2) joint-sparsity SENSE and 3) model-based SENSE. Four metrics were calculated on 3 naïve swine and 8 normal human subjects over a whole left-ventricular region of interest: root-mean-square error (RMSE) of image signal intensity, RMSE of T2, the bias of mean T2, and standard deviation (SD) of T2. Fully sampled data and volume-by-volume SENSE with standard equally spaced undersampling were used as references. The Jaccard index calculated from one swine with acute myocardial infarction (MI) was used to demonstrate preservation of segmentation of edematous tissues with elevated T2.ResultsIn naïve swine and normal human subjects, all methods had similar performance when the net reduction factor (Rnet) <2.5. VDR sampling with model-based SENSE showed the lowest RMSEs (10.5%-14.2%) and SDs (+1.7-2.4 ms) of T2 when Rnet>2.5, while VDR sampling with the joint-sparsity SENSE had the lowest bias of mean T2 (0.0-1.1ms) when Rnet>3. The RMSEs of parametric T2 values (9.2%-24.6%) were larger than for image signal intensities (5.2%-18.4%). In the swine with MI, VDR sampling with either joint-sparsity or model-based SENSE showed consistently higher Jaccard index for all Rnet (0.71-0.50) than volume-by-volume SENSE (0.68-0.30).ConclusionsRetrospective exploration of undersampling and reconstruction in 3D whole-heart T2 parametric mapping revealed that maps were more sensitive to undersampling than images, presenting a more stringent limiting factor on Rnet. The combination of VDR sampling patterns with model-based or joint-sparsity SENSE reconstructions were more robust for Rnet>3.

Project description:Introduction: The US Environmental Protection Agency Toxicity Forecaster (ToxCast) program makes in vitro medium- and high-throughput screening assay data publicly available for prioritization and hazard characterization of thousands of chemicals. The assays employ a variety of technologies to evaluate the effects of chemical exposure on diverse biological targets, from distinct proteins to more complex cellular processes like mitochondrial toxicity, nuclear receptor signaling, immune responses, and developmental toxicity. The ToxCast data pipeline (tcpl) is an open-source R package that stores, manages, curve-fits, and visualizes ToxCast data and populates the linked MySQL Database, invitrodb. Methods: Herein we describe major updates to tcpl and invitrodb to accommodate a new curve-fitting approach. The original tcpl curve-fitting models (constant, Hill, and gain-loss models) have been expanded to include Polynomial 1 (Linear), Polynomial 2 (Quadratic), Power, Exponential 2, Exponential 3, Exponential 4, and Exponential 5 based on BMDExpress and encoded by the R package dependency, tcplfit2. Inclusion of these models impacted invitrodb (beta version v4.0) and tcpl v3 in several ways: (1) long-format storage of generic modeling parameters to permit additional curve-fitting models; (2) updated logic for winning model selection; (3) continuous hit calling logic; and (4) removal of redundant endpoints as a result of bidirectional fitting. Results and discussion: Overall, the hit call and potency estimates were largely consistent between invitrodb v3.5 and 4.0. Tcpl and invitrodb provide a standard for consistent and reproducible curve-fitting and data management for diverse, targeted in vitro assay data with readily available documentation, thus enabling sharing and use of these data in myriad toxicology applications. The software and database updates described herein promote comparability across multiple tiers of data within the US Environmental Protection Agency CompTox Blueprint.

Dataset Information

SUPER: A blockwise curve-fitting method for accelerating MR parametric mapping with fast reconstruction.

Publications

SUPER: A blockwise curve-fitting method for accelerating MR parametric mapping with fast reconstruction.

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