Unknown

Dataset Information

0

Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model.


ABSTRACT: Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult-euthanasia by isoflurane overdose-are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle diversity increases. Contribution of the retinal vasculature to scattering angle diversity is discussed. Results of this study suggest the utility of SAR-OCT to measure TE using scattering angle diversity contrast in the retina.

SUBMITTER: Gardner MR 

PROVIDER: S-EPMC6440039 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

altmetric image

Publications

Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model.

Gardner Michael R MR   Rahman Ayesha S AS   Milner Thomas E TE   Rylander Henry G HG  

Journal of experimental neuroscience 20190327


Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult-euthanasia by isoflurane overdose-are presented. A total of 4 SAR-OCT measurement parameters are reported  ...[more]

Similar Datasets

| S-EPMC7401921 | biostudies-literature
| S-EPMC5749255 | biostudies-literature
| S-EPMC10944478 | biostudies-literature
| S-EPMC3296548 | biostudies-literature
| S-EPMC5634666 | biostudies-literature
| S-EPMC6502067 | biostudies-literature
| S-EPMC9299665 | biostudies-literature
| S-EPMC3178313 | biostudies-other
| S-EPMC5788978 | biostudies-literature
| S-EPMC5099988 | biostudies-literature