Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.
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ABSTRACT:
SUBMITTER: Hwang CS
PROVIDER: S-EPMC6442938 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.
Hwang Candy S CS Ellis Beverly B Zhou Bin B Janda Kim D KD
Bioorganic & medicinal chemistry 20181120 1
Heroin is a highly abused opioid that has reached epidemic status within the United States. Yet, existing therapies to treat addiction are inadequate and frequently result into rates of high recidivism. Vaccination against heroin offers a promising alternative therapeutic option but requires further development to enhance the vaccine's performance. Hsp70 is a conserved protein with known immunomodulatory properties and is considered an excellent immunodominant antigen. Within an antidrug vaccine ...[more]
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