Ontology highlight
ABSTRACT:
SUBMITTER: Jones DJ
PROVIDER: S-EPMC6444443 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Jones David J DJ O'Leary Eileen M EM O'Sullivan Timothy P TP
Beilstein journal of organic chemistry 20190329
An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium <i>tert</i>-butoxide and DMF, to achieve high conversions to the target. A systematic study within our laboratory led to the identification of an iodide reagent which affords higher yields than previous approaches and allows for reactions to be conducted up to 10 g in scale under mil ...[more]