Ontology highlight
ABSTRACT:
SUBMITTER: Chou-Zheng L
PROVIDER: S-EPMC6447361 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chou-Zheng Lucy L Hatoum-Aslan Asma A
eLife 20190403
CRISPR-Cas systems provide sequence-specific immunity against phages and mobile genetic elements using CRISPR-associated nucleases guided by short CRISPR RNAs (crRNAs). Type III systems exhibit a robust immune response that can lead to the extinction of a phage population, a feat coordinated by a multi-subunit effector complex that destroys invading DNA and RNA. Here, we demonstrate that a model type III system in <i>Staphylococcus epidermidis</i> relies upon the activities of two degradosome-as ...[more]