Ontology highlight
ABSTRACT:
SUBMITTER: D'Acunzo P
PROVIDER: S-EPMC6449392 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
D'Acunzo Pasquale P Strappazzon Flavie F Caruana Ignazio I Meneghetti Giacomo G Di Rita Anthea A Simula Luca L Weber Gerrit G Del Bufalo Francesca F Dalla Valle Luisa L Campello Silvia S Locatelli Franco F Cecconi Francesco F
Nature communications 20190404 1
Autophagy-mediated degradation of mitochondria (mitophagy) is a key process in cellular quality control. Although mitophagy impairment is involved in several patho-physiological conditions, valuable methods to induce mitophagy with low toxicity in vivo are still lacking. Herein, we describe a new optogenetic tool to stimulate mitophagy, based on light-dependent recruitment of pro-autophagy protein AMBRA1 to mitochondrial surface. Upon illumination, AMBRA1-RFP-sspB is efficiently relocated from t ...[more]