Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC6450455 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.
Chen Xike X Yamashita Akihiro A Morioka Miho M Senba Toshika T Kamatani Takashi T Watanabe Akira A Kosai Azuma A Tsumaki Noriyuki N
Tissue engineering. Part A 20181003 5-6
<h4>Impact statement</h4>Cartilage particles derived from human induced pluripotent stem cells (hiPS-Carts) are one candidate source for transplants for treatment of articular cartilage damage. This study shows that hiPS-Carts integrate with each other in an <i>in vitro</i> model and analyzed the course of the integration. The integration starts at the perichondrium-like membrane at around 1 week and then progresses to the central cartilage within 4-8 weeks. The results indicate that FGF18 secre ...[more]
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