Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC6450755 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zhang Lingdi L Vielle Anne A Espinosa Sara S Zhao Rui R
Wiley interdisciplinary reviews. RNA 20190206 3
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton RNA-protein complex. The spliceosome undergoes dramatic compositional and conformational changes through the splicing cycle, forming at least 10 distinct complexes. Recent high-resolution cryoEM structures of various spliceosomal complexes revealed unprecedented details of this large molecular machine. This review highlights insight into the structure and function of the spliceosomal RNA components obtained from these new struc ...[more]