Ontology highlight
ABSTRACT:
SUBMITTER: Kok T
PROVIDER: S-EPMC6453109 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Drug discovery today 20180621 11
Macrophage migration inhibitory factor (MIF) is an important cytokine for which an increasing number of functions is being described in the pathogenesis of inflammation and cancer. Nevertheless, the availability of potent and druglike MIF inhibitors that are well-characterized in relevant disease models remains limited. Development of highly potent and selective small-molecule MIF inhibitors and validation of their use in relevant disease models will advance drug discovery. In this review, we pr ...[more]