Ontology highlight
ABSTRACT:
SUBMITTER: Gray RD
PROVIDER: S-EPMC6455816 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
The journal of physical chemistry letters 20190227 5
Circular dichroism and stopped-flow UV spectroscopies were used to investigate the thermodynamic stability and the folding pathway of d[TGAG<sub>3</sub>TG<sub>3</sub>TAG<sub>3</sub>TG<sub>3</sub>TA<sub>2</sub>] at 25 °C in solutions containing 25 mM KCl. Under these conditions the oligonucleotide adopts a thermally stable, all-parallel G-quadruplex topography containing three stacked quartets. K<sup>+</sup>-induced folding shows three resolved relaxation times, each with distinctive spectral cha ...[more]