Ontology highlight
ABSTRACT:
SUBMITTER: Shang L
PROVIDER: S-EPMC6455945 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Shang L L Smith A J AJ Duan L L Perkey K E KE Wietgrefe S S Zupancic M M Southern P J PJ Johnson R P RP Carlis J V JV Haase A T AT
The Journal of infectious diseases 20180901 8
To identify the mechanisms by which human immunodeficiency virus type 1 (HIV-1) might penetrate the epithelial barrier during sexual transmission to women and the mechanisms of vaccine-associated protection against entry, we characterized early epithelial responses to vaginal inoculation of simian immunodeficiency virus strain mac251 (SIVmac251) in naive or SIVmac239Δnef-vaccinated rhesus macaques. Vaginal inoculation induced an early stress response in the cervicovaginal epithelium, which was a ...[more]