Differences in the rate of nicotine metabolism among smokers with and without HIV.

ABSTRACT: OBJECTIVE:HIV-infected smokers lose more life years to tobacco use than to HIV infection. The nicotine metabolite ratio (NMR), a biomarker of CYP2A6, represents individual variation in the rate at which nicotine is metabolized and is associated with response to smoking cessation treatments. We evaluated whether HIV-infected smokers metabolize nicotine faster than HIV-uninfected smokers, which may contribute to the disproportionate smoking burden and may have important treatment implications. DESIGN:We analysed baseline data from two clinical trials (NCT01710137; NCT01314001) to compare the NMR in HIV-infected smokers (N?=?131) to HIV-uninfected smokers (N?=?199). METHODS:Propensity scores were used to match the groups 2?:?1 on characteristics that influence NMR: sex, race, BMI and smoking rate. Nicotine metabolites were assessed via liquid chromatography-tandem mass spectrometry methods and the ratio of 3-hydroxycotinine:cotinine was used to compute the NMR. RESULTS:HIV-infected smokers had significantly higher NMR (mean?=?0.47, SEM?=?0.02) and were more likely to be in the highest NMR quartile compared with HIV-uninfected smokers (mean?=?0.34, SEM?=?0.02; Ps?

SUBMITTER: Ashare RL 

PROVIDER: S-EPMC6457129 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature