Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC6462403 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zhang Jinfang J Chen Ming M Zhu Yasheng Y Dai Xiangpeng X Dang Fabin F Ren Junming J Ren Shancheng S Shulga Yulia V YV Beca Francisco F Gan Wenjian W Wu Fei F Lin Yu-Min YM Zhou Xiaobo X DeCaprio James A JA Beck Andrew H AH Lu Kun Ping KP Huang Jiaoti J Zhao Cheryl C Sun Yinghao Y Gao Xu X Pandolfi Pier Paolo PP Wei Wenyi W
Developmental cell 20181227 3
Frequent SPOP mutation defines the molecular feature underlying one of seven sub-types of human prostate cancer (PrCa). However, it remains largely elusive how SPOP functions as a tumor suppressor in PrCa. Here, we report that SPOP suppresses stem cell traits of both embryonic stem cells and PrCa cells through promoting Nanog poly-ubiquitination and subsequent degradation. Mechanistically, Nanog, but not other pluripotency-determining factors including Oct4, Sox2, and Klf4, specifically interact ...[more]