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ABSTRACT: Editorial note
This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
SUBMITTER: Kuwahara ST
PROVIDER: S-EPMC6464605 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Kuwahara Stephanie T ST Serowoky Maxwell A MA Vakhshori Venus V Tripuraneni Nikita N Hegde Neel V NV Lieberman Jay R JR Crump J Gage JG Mariani Francesca V FV
eLife 20190415
Most bones in mammals display a limited capacity for natural large-scale repair. The ribs are a notable exception, yet the source of their remarkable regenerative ability remains unknown. Here, we identify a <i>Sox9</i>-expressing periosteal subpopulation that orchestrates large-scale regeneration of murine rib bones. Deletion of the obligate Hedgehog co-receptor, <i>Smoothened</i>, in <i>Sox9</i>-expressing cells prior to injury results in a near-complete loss of callus formation and rib bone r ...[more]