Ontology highlight
ABSTRACT:
SUBMITTER: Xiao H
PROVIDER: S-EPMC6465249 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Xiao Haixia H Guo Tianling T Yang Mi M Qi Jianxun J Huang Chaobin C Hong Yuanyuan Y Gu Jinjin J Pang Xuefei X Liu William Jun WJ Peng Ruchao R McCauley John J Bi Yuhai Y Li Shihua S Feng Junxia J Zhang Hailiang H Zhang Xupei X Lu Xishan X Yan Jinghua J Chen Liling L Shi Yi Y Chen Weizhi W Gao George Fu GF
Cell discovery 20190416
The isolation of human monoclonal antibodies with broadly neutralizing breadth can provide a promising countermeasure for influenza A viruses infection. Most broadly neutralizing antibodies against influenza A viruses bind to the conserved stem region or the receptor-binding cavity of hemagglutinin and the interaction is dominated by the heavy chain. The light chain, however, contributes few or no direct contacts to the antigen. Here we report an H3-clade neutralizing human monoclonal antibody, ...[more]