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Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential.

ABSTRACT: Proteins have sparked fast growing interest as biological therapeutic agents for several diseases. Antibodies, in particular, carry an enormous potential as drugs owing to their remarkable target specificity and low immunogenicity. Although the market has numerous antibodies directed toward extracellular targets, their use in targeting therapeutically important intracellular targets is limited by their inability to cross cellular membrane. Realizing the potential for antibody therapy in disease treatment, progress has been made in the development of methods to deliver antibodies intracellularly. In this review, we address various platforms for delivery of antibodies and their merits and drawbacks.

SUBMITTER: Singh K

PROVIDER: S-EPMC6470022 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential.

Singh Khushboo K Ejaz Wardah W Dutta Kingshuk K Thayumanavan S S

Bioconjugate chemistry 20190318 4

Proteins have sparked fast growing interest as biological therapeutic agents for several diseases. Antibodies, in particular, carry an enormous potential as drugs owing to their remarkable target specificity and low immunogenicity. Although the market has numerous antibodies directed toward extracellular targets, their use in targeting therapeutically important intracellular targets is limited by their inability to cross cellular membrane. Realizing the potential for antibody therapy in disease ...[more]

PMID: 30830750

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