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Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636.

ABSTRACT: Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 ?g/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 ?g/mL, respectively.

SUBMITTER: Xu X

PROVIDER: S-EPMC6471054 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636.

Xu Xiuli X Han Jiahui J Lin Rui R Polyak Steven W SW Song Fuhang F

Marine drugs 20190321 3

Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibit ...[more]

PMID: 30901830

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