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Lack of Response to Imatinib in Melanoma Carrying Rare KIT Mutation p.T632I.


ABSTRACT: Approximately 15% of acral and mucous melanomas carry activating mutations in KIT oncogene. There is a diversity of spectrum of KIT mutations, with some of them rendering tumors responsive to imatinib, while others being imatinib-resistant or not studied yet. Here we present an acral melanoma patient with KIT ?.T632I mutation, who failed to respond to imatinib.

SUBMITTER: Orlova KV 

PROVIDER: S-EPMC6477486 | biostudies-literature | 2019 Jan-Apr

REPOSITORIES: biostudies-literature

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