Targeting the PD-1/PD-L1 Pathway in Renal Cell Carcinoma.
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ABSTRACT:
SUBMITTER: Kammerer-Jacquet SF
PROVIDER: S-EPMC6480014 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting the PD-1/PD-L1 Pathway in Renal Cell Carcinoma.
Kammerer-Jacquet Solène-Florence SF Deleuze Antoine A Saout Judikaël J Mathieu Romain R Laguerre Brigitte B Verhoest Gregory G Dugay Frédéric F Belaud-Rotureau Marc-Antoine MA Bensalah Karim K Rioux-Leclercq Nathalie N
International journal of molecular sciences 20190404 7
Renal cell carcinoma encompass distinct diseases with different pathologic features and distinct molecular pathways. Immune checkpoint inhibitors targeting the programmed death receptor ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) pathway alone or in combination have greatly changed clinical management of metastatic renal cell carcinoma, now competing with antiangiogenic drugs in monotherapy for first-line treatment. However, long-term response rates are low, and biomarkers are needed to ...[more]
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