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A New Approach for Glyco-Functionalization of Collagen-Based Biomaterials.


ABSTRACT: The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of affordable chemoselective methods for ECM components glycosylation is desirable. We will describe a new chemoselective glycosylation approach exploitable in aqueous media and on non-protected substrates, allowing rapid access to glyco-functionalized biomaterials.

SUBMITTER: Figuereido I 

PROVIDER: S-EPMC6480084 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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A New Approach for Glyco-Functionalization of Collagen-Based Biomaterials.

Figuereido Ines I   Paiotta Alice A   Dal Magro Roberta R   Tinelli Francesca F   Corti Roberta R   Re Francesca F   Cassina Valeria V   Caneva Enrico E   Nicotra Francesco F   Russo Laura L  

International journal of molecular sciences 20190409 7


The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of a  ...[more]

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