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Acute aerobic exercise effects on cognitive function in breast cancer survivors: a randomized crossover trial.

ABSTRACT: BACKGROUND:Many breast cancer survivors (BCS) report deficits in cognitive function. Physical activity (PA) has been associated with better processing speed and memory in healthy adults and thus may be a useful method for improving cognition in BCS. The purpose of this study was to examine the effects of an acute bout of PA on processing speed and spatial working memory in a sample of BCS. METHODS:Using a repeated measures, crossover design, BCS [N?=?27; Mage (SD)?=?49.11(8.05)] completed two sessions in counterbalanced order: 30?min of moderate-intensity treadmill walking and 30?min of seated rest. Women completed cognitive tasks immediately before and after each session. RESULTS:Within-subjects repeated measures analyses of variance revealed a significant time by session effect for processing speed reaction time [F (1,25)?=?5.02, p?=?.03, ?2?=?0.17]. This interaction was driven by significantly reduced reaction time (e.g., faster response) post-exercise and no change post-rest. Further between-subjects analyses indicated a significant time by session by moderate to vigorous physical activity (MVPA) split [F (1,25)?=?5.23, p?=?.03, ?2?=?0.17], such that women who engaged in ?45?min of average daily MVPA reduced their reaction time post-exercise (p?=?.01) and increased RT post-rest (p?=?.06). Time by session effects for spatial working memory 3-item accuracy and 4-item reaction time trended towards significance, p?=?0.08 and p?=?0.10, respectively, again driven by better performance post-exercise. CONCLUSIONS:The moderate effect of acute exercise on domains of memory and processing speed in BCS is encouraging. Cancer-related cognitive impairment remains largely misunderstood; however, the results from the present study offer preliminary evidence for the positive relationship between acute exercise and cognition in BCS. TRIAL REGISTRATION:ClinicalTrials.gov NCT02592070 . Registered 30 October 2015. Retroactively registered.

SUBMITTER: Salerno EA

PROVIDER: S-EPMC6480426 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Acute aerobic exercise effects on cognitive function in breast cancer survivors: a randomized crossover trial.

Salerno Elizabeth A EA Rowland Kendrith K Kramer Arthur F AF McAuley Edward E

BMC cancer 20190423 1

<h4>Background</h4>Many breast cancer survivors (BCS) report deficits in cognitive function. Physical activity (PA) has been associated with better processing speed and memory in healthy adults and thus may be a useful method for improving cognition in BCS. The purpose of this study was to examine the effects of an acute bout of PA on processing speed and spatial working memory in a sample of BCS.<h4>Methods</h4>Using a repeated measures, crossover design, BCS [N = 27; M<sub>age</sub> (SD) = 49. ...[more]

PMID: 31014267

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Project description:ObjectiveTo assess the efficacy of a progressive aerobic exercise training program on cognitive and everyday function among adults with mild subcortical ischemic vascular cognitive impairment (SIVCI).MethodsThis was a proof-of-concept single-blind randomized controlled trial comparing a 6-month, thrice-weekly, progressive aerobic exercise training program (AT) with usual care plus education on cognitive and everyday function with a follow-up assessment 6 months after the formal cessation of aerobic exercise training. Primary outcomes assessed were general cognitive function (Alzheimer's Disease Assessment Scale-Cognitive subscale [ADAS-Cog]), executive functions (Executive Interview [EXIT-25]), and activities of daily living (Alzheimer's Disease Cooperative Study-Activities of Daily Living [ADCS-ADL]).ResultsSeventy adults randomized to aerobic exercise training or usual care were included in intention-to-treat analyses (mean age 74 years, 51% female, n = 35 per group). At the end of the intervention, the aerobic exercise training group had significantly improved ADAS-Cog performance compared with the usual care plus education group (-1.71 point difference, 95% confidence interval [CI] -3.15 to -0.26, p = 0.02); however, this difference was not significant at the 6-month follow-up (-0.63 point difference, 95% CI -2.34 to 1.07, p = 0.46). There were no significant between-group differences at intervention completion and at the 6-month follow-up in EXIT-25 or ADCS-ADL performance. Examination of secondary measures showed between-group differences at intervention completion favoring the AT group in 6-minute walk distance (30.35 meter difference, 95% CI 5.82 to 54.86, p = 0.02) and in diastolic blood pressure (-6.89 mm Hg difference, 95% CI -12.52 to -1.26, p = 0.02).ConclusionsThis study provides preliminary evidence for the efficacy of 6 months of thrice-weekly progressive aerobic training in community-dwelling adults with mild SIVCI, relative to usual care plus education.Clinicaltrialsgov identifierNCT01027858.Classification of evidenceThis study provides Class II evidence that for adults with mild SIVCI, an aerobic exercise program for 6 months results in a small, significant improvement in ADAS-Cog performance.

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Acute aerobic exercise effects on cognitive function in breast cancer survivors: a randomized crossover trial.

Publications

Acute aerobic exercise effects on cognitive function in breast cancer survivors: a randomized crossover trial.

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