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Dose-Response Effects of Acute Aerobic Exercise Duration on Cognitive Function in Patients With Breast Cancer: A Randomized Crossover Trial.

ABSTRACT: Objective:To examine the differential effects of acute exercise duration on domains of executive function and processing speed in patients with breast cancer. Methods:Participants (N = 48, M age = 56.02 ± 10.99) completed two sessions in counterbalanced order: moderate-intensity treadmill walking and sitting. Participants were also randomized to one of three duration conditions: 10 (n = 15), 20 (n = 16), or 30 (n = 17) min, reflecting the length of time spent walking and sitting. Immediately before and after each session, women completed a battery of cognitive tasks (e.g., inhibition, cognitive flexibility, spatial working memory, and processing speed). Results:Within- and between-subjects repeated-measures analyses of variance revealed time by condition interactions on both processing speed (p = 0.02) and spatial working memory (ps < 0.07), such that women demonstrated improved cognitive functioning regardless of the time spent walking. There were also several moderately sized three-way (e.g., time by condition by duration) interactions driven by declines in cognitive functioning after sitting on cognitive flexibility in the 10 (d = -0.96) and 30-min (d = -0.52) groups and inhibition in the 20-min group (d = 0.75). On the processing speed task, women performed significantly faster after walking compared with after sitting in the 20-min group (d = -0.24). Conclusions:For select cognitive domains, walking anywhere from 10 to 30 min is associated with significant benefits. Our findings suggest the need for further research into the mechanisms and dose-response relationships between acute exercise and cognition as well as how such acute bouts may be accumulated for larger, lasting cognitive benefits after breast cancer. Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT04255225.

SUBMITTER: Salerno EA

PROVIDER: S-EPMC7371984 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Dose-Response Effects of Acute Aerobic Exercise Duration on Cognitive Function in Patients With Breast Cancer: A Randomized Crossover Trial.

Salerno Elizabeth A EA Rowland Kendrith K Hillman Charles H CH Trinh Linda L Kramer Arthur F AF McAuley Edward E

Frontiers in psychology 20200714

<h4>Objective</h4>To examine the differential effects of acute exercise duration on domains of executive function and processing speed in patients with breast cancer.<h4>Methods</h4>Participants (<i>N</i> = 48, <i>M</i> <sub>age</sub> = 56.02 ± 10.99) completed two sessions in counterbalanced order: moderate-intensity treadmill walking and sitting. Participants were also randomized to one of three duration conditions: 10 (<i>n</i> = 15), 20 (<i>n</i> = 16), or 30 (<i>n</i> = 17) min, reflecting ...[more]

PMID: 32760319

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Project description:BackgroundMany breast cancer survivors (BCS) report deficits in cognitive function. Physical activity (PA) has been associated with better processing speed and memory in healthy adults and thus may be a useful method for improving cognition in BCS. The purpose of this study was to examine the effects of an acute bout of PA on processing speed and spatial working memory in a sample of BCS.MethodsUsing a repeated measures, crossover design, BCS [N = 27; Mage (SD) = 49.11(8.05)] completed two sessions in counterbalanced order: 30 min of moderate-intensity treadmill walking and 30 min of seated rest. Women completed cognitive tasks immediately before and after each session.ResultsWithin-subjects repeated measures analyses of variance revealed a significant time by session effect for processing speed reaction time [F (1,25) = 5.02, p = .03, η2 = 0.17]. This interaction was driven by significantly reduced reaction time (e.g., faster response) post-exercise and no change post-rest. Further between-subjects analyses indicated a significant time by session by moderate to vigorous physical activity (MVPA) split [F (1,25) = 5.23, p = .03, η2 = 0.17], such that women who engaged in ≥45 min of average daily MVPA reduced their reaction time post-exercise (p = .01) and increased RT post-rest (p = .06). Time by session effects for spatial working memory 3-item accuracy and 4-item reaction time trended towards significance, p = 0.08 and p = 0.10, respectively, again driven by better performance post-exercise.ConclusionsThe moderate effect of acute exercise on domains of memory and processing speed in BCS is encouraging. Cancer-related cognitive impairment remains largely misunderstood; however, the results from the present study offer preliminary evidence for the positive relationship between acute exercise and cognition in BCS.Trial registrationClinicalTrials.gov NCT02592070 . Registered 30 October 2015. Retroactively registered.

Project description:ObjectiveTo assess the efficacy of a progressive aerobic exercise training program on cognitive and everyday function among adults with mild subcortical ischemic vascular cognitive impairment (SIVCI).MethodsThis was a proof-of-concept single-blind randomized controlled trial comparing a 6-month, thrice-weekly, progressive aerobic exercise training program (AT) with usual care plus education on cognitive and everyday function with a follow-up assessment 6 months after the formal cessation of aerobic exercise training. Primary outcomes assessed were general cognitive function (Alzheimer's Disease Assessment Scale-Cognitive subscale [ADAS-Cog]), executive functions (Executive Interview [EXIT-25]), and activities of daily living (Alzheimer's Disease Cooperative Study-Activities of Daily Living [ADCS-ADL]).ResultsSeventy adults randomized to aerobic exercise training or usual care were included in intention-to-treat analyses (mean age 74 years, 51% female, n = 35 per group). At the end of the intervention, the aerobic exercise training group had significantly improved ADAS-Cog performance compared with the usual care plus education group (-1.71 point difference, 95% confidence interval [CI] -3.15 to -0.26, p = 0.02); however, this difference was not significant at the 6-month follow-up (-0.63 point difference, 95% CI -2.34 to 1.07, p = 0.46). There were no significant between-group differences at intervention completion and at the 6-month follow-up in EXIT-25 or ADCS-ADL performance. Examination of secondary measures showed between-group differences at intervention completion favoring the AT group in 6-minute walk distance (30.35 meter difference, 95% CI 5.82 to 54.86, p = 0.02) and in diastolic blood pressure (-6.89 mm Hg difference, 95% CI -12.52 to -1.26, p = 0.02).ConclusionsThis study provides preliminary evidence for the efficacy of 6 months of thrice-weekly progressive aerobic training in community-dwelling adults with mild SIVCI, relative to usual care plus education.Clinicaltrialsgov identifierNCT01027858.Classification of evidenceThis study provides Class II evidence that for adults with mild SIVCI, an aerobic exercise program for 6 months results in a small, significant improvement in ADAS-Cog performance.

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Dose-Response Effects of Acute Aerobic Exercise Duration on Cognitive Function in Patients With Breast Cancer: A Randomized Crossover Trial.

Publications

Dose-Response Effects of Acute Aerobic Exercise Duration on Cognitive Function in Patients With Breast Cancer: A Randomized Crossover Trial.

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