Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Worldwide Frequencies of APOL1 Renal Risk Variants.

ABSTRACT:

SUBMITTER: Nadkarni GN

PROVIDER: S-EPMC6482949 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Worldwide Frequencies of APOL1 Renal Risk Variants.

Nadkarni Girish N GN Gignoux Christopher R CR Sorokin Elena P EP Daya Michelle M Rahman Rayees R Barnes Kathleen C KC Wassel Christina L CL Kenny Eimear E EE

The New England journal of medicine 20181201 26

PMID: 30586505

Similar Datasets

APOL1 renal-risk variants induce mitochondrial dysfunction

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-08-23 | E-GEOD-85921 | biostudies-arrayexpress

APOL1 renal-risk variants induce mitochondrial fission

Project description:To assess gene expression by APOL1 genotypes in primary proximal tubule cells (PTCs), global gene expression (mRNA) levels were examined on Affymetrix HTA 2.0 arrays in primary PTCs cultured from non-diseased kidney in African Americans without CKD who underwent nephrectomy for localized renal cell carcinoma.

2018-09-15 | GSE119958 | GEO

APOL1 renal-risk variants induce mitochondrial dysfunction

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-08-23 | GSE85921 | GEO

APOL1 renal-risk variants induce mitochondrial dysfunction (Illumina)

Project description:To elucidate pathways whereby apolipoprotein L1 gene (APOL1) G1 and G2 variants facilitate kidney disease in African Americans, human embryonic kidney cells (HEK293) were used to establish doxycycline-inducible (Tet-on) cell lines stably expressing reference APOL1 G0 and its G1 and G2 renal-risk variants. Illumina human HT-12-v4 arrays and Affymetrix HTA 2.0 arrays were employed to generate global gene expression data with doxycycline induction. Significantly altered pathways identified through bioinformatics involved mitochondrial function; results were validated using immunoblotting, immunofluorescence and functional assays. Global gene expression profiles were performed on HEK293 Tet-on G0, G1, G2 and empty vector cells with and without Dox induction using Illumina human HT-12 v4 arrays. Another independent gene expression array system, Affymetrix HTA 2.0, was used to verify the results of Illumina arrays. Pair-wise and pattern-based analyses were applied to detect the mostly impacted pathways due to overexpression and by APOL1 genotypes.

2016-08-23 | E-GEOD-85918 | biostudies-arrayexpress

APOL1 renal-risk variants induce mitochondrial dysfunction (Illumina)

2016-08-23 | GSE85918 | GEO

APOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 2)

Project description:To assess differential gene expression by APOL1 renal-risk (2 risk alleles) vs. non-risk (G0G0) genotypes in primary proximal tubule cells (PTCs), global gene expression (mRNA) levels were examined on Affymetrix HTA 2.0 arrays in primary PTCs cultured from non-diseased kidney in African Americans without CKD who underwent nephrectomy for localized renal cell carcinoma. To detect differentially expressed gene profiles attributable to APOL1 renal-risk genotypes, African American primary proximal tubule cells with two APOL1 renal-risk alleles (N=5) and lacking renal-risk alleles (N=25) were included in comparisons of global gene expression.

2016-08-23 | E-GEOD-85920 | biostudies-arrayexpress

APOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 2)

2016-08-23 | GSE85920 | GEO

APOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 1)

2016-08-23 | GSE85919 | GEO