Ontology highlight
ABSTRACT:
SUBMITTER: Raouf R
PROVIDER: S-EPMC6485395 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Raouf Ramin R Lolignier Stéphane S Sexton Jane E JE Millet Queensta Q Santana-Varela Sonia S Biller Anna A Fuller Alice M AM Pereira Vanessa V Choudhary Jyoti S JS Collins Mark O MO Moss Stephen E SE Lewis Richard R Tordo Julie J Henckaerts Els E Linden Michael M Wood John N JN
Science signaling 20180619 535
Mechanically activated, slowly adapting currents in sensory neurons have been linked to noxious mechanosensation. The conotoxin NMB-1 (noxious mechanosensation blocker-1) blocks such currents and inhibits mechanical pain. Using a biotinylated form of NMB-1 in mass spectrometry analysis, we identified 67 binding proteins in sensory neurons and a sensory neuron-derived cell line, of which the top candidate was annexin A6, a membrane-associated calcium-binding protein. Annexin A6-deficient mice sho ...[more]