Ontology highlight
ABSTRACT:
SUBMITTER: Tay JH
PROVIDER: S-EPMC6486442 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Tay Jia-Hui JH Dorokhov Valentin V Wang Sibin S Nagorny Pavel P
The Journal of antibiotics 20190404 6
This manuscript describes a single pot protocol for the selective introduction of unprotected sugars to the C3 position of the cardiotonic steroid strophanthidol. These reactions proceed with high levels of regiocontrol (>20:1 rr) in the presence of three other hydroxyl functionalities including the C19 primary hydroxyl group and could be applied to different sugars to provide the deprotected cardiac glycosides upon work up (5 examples, 77-69% yield per single operation). The selective glycosyla ...[more]