Ontology highlight
ABSTRACT:
SUBMITTER: Gigante S
PROVIDER: S-EPMC6486641 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Gigante Scott S Gouil Quentin Q Lucattini Alexis A Keniry Andrew A Beck Tamara T Tinning Matthew M Gordon Lavinia L Woodruff Chris C Speed Terence P TP Blewitt Marnie E ME Ritchie Matthew E ME
Nucleic acids research 20190501 8
Systematic variation in the methylation of cytosines at CpG sites plays a critical role in early development of humans and other mammals. Of particular interest are regions of differential methylation between parental alleles, as these often dictate monoallelic gene expression, resulting in parent of origin specific control of the embryonic transcriptome and subsequent development, in a phenomenon known as genomic imprinting. Using long-read nanopore sequencing we show that, with an average geno ...[more]