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Para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis.

ABSTRACT: Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under aerobic conditions.

SUBMITTER: Naksomboon K

PROVIDER: S-EPMC6487392 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis.

Naksomboon Kananat K Poater Jordi J Bickelhaupt F Matthias FM Fernández-Ibáñez M Ángeles MÁ

Journal of the American Chemical Society 20190412 16

Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under ae ...[more]

PMID: 30922056

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