Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC6488461 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhu Qian Q Shah Sheel S Dries Ruben R Cai Long L Yuan Guo-Cheng GC
Nature biotechnology 20181029
How intrinsic gene-regulatory networks interact with a cell's spatial environment to define its identity remains poorly understood. We developed an approach to distinguish between intrinsic and extrinsic effects on global gene expression by integrating analysis of sequencing-based and imaging-based single-cell transcriptomic profiles, using cross-platform cell type mapping combined with a hidden Markov random field model. We applied this approach to dissect the cell-type- and spatial-domain-asso ...[more]