Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure.
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ABSTRACT:
SUBMITTER: Gardner GT
PROVIDER: S-EPMC6488766 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure.
Gardner George T GT Travers Joshua G JG Qian Jiang J Liu Guan-Sheng GS Haghighi Kobra K Robbins Nathan N Jiang Min M Li Yutian Y Fan Guo-Chang GC Rubinstein Jack J Blaxall Burns C BC Kranias Evangelia G EG
JACC. Basic to translational science 20190429 2
Cardiomyocyte-specific increases in phosphorylated Hsp20 (S16D-Hsp20) to levels similar to those observed in human failing hearts are associated with early fibrotic remodeling and depressed left ventricular function, symptoms which progress to heart failure and early death. The underlying mechanisms appear to involve translocation of phosphorylated Hsp20 to the nucleus and upregulation of interleukin (IL)-6, which subsequently activates cardiac fibroblasts in a paracrine fashion through transcri ...[more]
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