Ontology highlight
ABSTRACT:
SUBMITTER: Demonbreun AR
PROVIDER: S-EPMC9431694 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Demonbreun Alexis R AR Bogdanovic Elena E Vaught Lauren A LA Reiser Nina L NL Fallon Katherine S KS Long Ashlee M AM Oosterbaan Claire C CC Hadhazy Michele M Page Patrick Gt PG Joseph Prem Raj B PRB Cowen Gabrielle G Telenson Alexander M AM Khatri Ammaarah A Sadleir Katherine R KR Vassar Robert R McNally Elizabeth M EM
JCI insight 20220722 14
Membrane instability and disruption underlie myriad acute and chronic disorders. Anxa6 encodes the membrane-associated protein annexin A6 and was identified as a genetic modifier of muscle repair and muscular dystrophy. To evaluate annexin A6's role in membrane repair in vivo, we inserted sequences encoding green fluorescent protein (GFP) into the last coding exon of Anxa6. Heterozygous Anxa6gfp mice expressed a normal pattern of annexin A6 with reduced annexin A6GFP mRNA and protein. High-resol ...[more]